508 research outputs found
Low myo-inositol and high glutamine levels in brain are associated with neuropsychological deterioration after induced hyperammonemia
The neuropsychological effect of hyperammonemia is variable. This study tests the hypothesis that the effect of ammonia on the neuropsychological function in patients with cirrhosis is determined by the ability of the brain to buffer ammonia-induced increase in glutamine within the astrocyte by losing osmolytes like myo-inositol (mI) and not by the magnitude of the induced hyperammonemia. Fourteen cirrhotic patients with no evidence of overt hepatic encephalopathy were given a 75-g amino acid (aa) solution mimicking the hemoglobin molecule to induce hyperammonemia. Measurement of a battery of neuropsychological function tests including immediate memory, ammonia, aa, and short-echo time proton magnetic resonance spectroscopy were performed before and 4 h after administration of the as solution. Eight patients showed deterioration in the Immediate Memory Test at 4 h. Demographic factors, severity of liver disease, change in plasma ammonia, and as profiles after the as solution were similar in those that showed a deterioration compared with those who did not. In patients who showed deterioration in the memory test, the mI-to-creatine ratio (mI/Cr) was significantly lower at baseline than those that did not deteriorate. In contrast, the glutamate/glutamine-to-Cr ratio was significantly greater in the patients that deteriorated. The observation that deterioration in the memory test scores was greater in those with lower mI/Cr supports the hypothesis that the neuropsychological effects of induced hyperammonemia is determined by the capacity of the brain to handle ammonia-induced increase in glutamine
GNO Solar Neutrino Observations: Results for GNOI
We report the first GNO solar neutrino results for the measuring period GNOI,
solar exposure time May 20, 1998 till January 12, 2000. In the present
analysis, counting results for solar runs SR1 - SR19 were used till April 4,
2000. With counting completed for all but the last 3 runs (SR17 - SR19), the
GNO I result is [65.8 +10.2 -9.6 (stat.) +3.4 -3.6 (syst.)]SNU (1sigma) or
[65.8 + 10.7 -10.2 (incl. syst.)]SNU (1sigma) with errors combined. This may be
compared to the result for Gallex(I-IV), which is [77.5 +7.6 -7.8 (incl.
syst.)] SNU (1sigma). A combined result from both GNOI and Gallex(I-IV)
together is [74.1 + 6.7 -6.8 (incl. syst.)] SNU (1sigma).Comment: submitted to Physics Letters B, June 2000. PACS: 26.65. +t ; 14.60
Pq. Corresponding author: [email protected] ; [email protected]
A New Limit on the Neutrinoless DBD of 130Te
We report the present results of CUORICINO a cryogenic experiment on
neutrinoless double beta decay (DBD) of 130Te consisting of an array of 62
crystals of TeO2 with a total active mass of 40.7 kg. The array is framed
inside of a dilution refrigerator, heavily shielded against environmental
radioactivity and high-energy neutrons, and operated at a temperature of ~8 mK
in the Gran Sasso Underground Laboratory. Temperature pulses induced by
particle interacting in the crystals are recorded and measured by means of
Neutron Transmutation Doped thermistors. The gain of each bolometer is
stabilized with voltage pulses developed by a high stability pulse generator
across heater resistors put in thermal contact with the absorber.
The calibration is performed by means of two thoriated wires routinely
inserted in the set-up. No evidence for a peak indicating neutrinoless DBD of
130Te is detected and a 90% C.L. lower limit of 1.8E24 years is set for the
lifetime of this process. Taking largely into account the uncertainties in the
theoretical values of nuclear matrix elements, this implies an upper boud on
the effective mass of the electron neutrino ranging from 0.2 to 1.1 eV. This
sensitivity is similar to those of the 76Ge experiments.Comment: 4 pages, 2 figure
Complete results for five years of GNO solar neutrino observations
We report the complete GNO solar neutrino results for the measuring periods
GNO III, GNO II, and GNO I. The result for GNO III (last 15 solar runs) is
[54.3 + 9.9 - 9.3 (stat.)+- 2.3 (syst.)] SNU (1 sigma) or [54.3 + 10.2 - 9.6
(incl. syst.)] SNU (1 sigma) with errors combined. The GNO experiment is now
terminated after altogether 58 solar exposure runs that were performed between
May 20, 1998 and April 9, 2003. The combined result for GNO (I+II+III) is [62.9
+ 5.5 - 5.3 (stat.) +- 2.5 (syst.)] SNU (1 sigma) or [62.9 + 6.0 - 5.9] SNU (1
sigma) with errors combined in quadrature. Overall, gallium based solar
observations at LNGS (first in GALLEX, later in GNO) lasted from May 14, 1991
through April 9, 2003. The joint result from 123 runs in GNO and GALLEX is
[69.3 +- 5.5 (incl. syst.)] SNU (1 sigma). The distribution of the individual
run results is consistent with the hypothesis of a neutrino flux that is
constant in time. Implications from the data in particle- and astrophysics are
reiterated.Comment: 22 pages incl. 9 Figures and 8 Tables. to appear in: Physics Letters
B (accepted April 13, 2005) PACS: 26.65.+t ; 14.60.P
A Cryogenic Underground Observatory for Rare Events: Cuore, an Update
CUORE is a proposed tightly packed array of 1000 TeO_{2} bolometers, each
being a cube 5 cm on a side with a mass of 750 gms. The array consists of 25
vertical towers, arranged in a square, of 5 towers by 5 towers, each containing
10 layers of 4 crystals. The design of the detector is optimized for ultralow-
background searches for neutrinoless double beta decay of ^{130}Te (33.8%
abundance), cold dark matter, solar axions, and rare nuclear decays. A
preliminary experiment involving 20 crystals of various sizes (MIBETA) has been
completed, and a single CUORE tower is being constructed as a smaller scale
experiment called CUORICINO. The expected performance and sensitivity, based on
Monte Carlo simulations and extrapolations of present results, are reported.Comment: in press: Nucl. Phys. of Russian Academy of Sc
Double-beta decay of Te to the first 0 excited state of Xe with CUORICINO
The CUORICINO experiment was an array of 62 TeO single-crystal
bolometers with a total Te mass of kg. The experiment finished
in 2008 after more than 3 years of active operating time. Searches for both
and double-beta decay to the first excited state in
Xe were performed by studying different coincidence scenarios. The
analysis was based on data representing a total exposure of
N(Te)t=y. No evidence for a signal was
found. The resulting lower limits on the half lives are y (90% C.L.), and
y (90%
C.L.).Comment: 6 pages, 4 figure
The CUORE cryostat: an infrastructure for rare event searches at millikelvin temperatures
The CUORE experiment is the world's largest bolometric experiment. The
detector consists of an array of 988 TeO2 crystals, for a total mass of 742 kg.
CUORE is presently taking data at the Laboratori Nazionali del Gran Sasso,
Italy, searching for the neutrinoless double beta decay of 130Te. A large
custom cryogen-free cryostat allows reaching and maintaining a base temperature
of about 10 mK, required for the optimal operation of the detector. This
apparatus has been designed in order to achieve a low noise environment, with
minimal contribution to the radioactive background for the experiment. In this
paper, we present an overview of the CUORE cryostat, together with a
description of all its sub-systems, focusing on the solutions identified to
satisfy the stringent requirements. We briefly illustrate the various phases of
the cryostat commissioning and highlight the relevant steps and milestones
achieved each time. Finally, we describe the successful cooldown of CUORE
The Large Enriched Germanium Experiment for Neutrinoless Double Beta Decay (LEGEND)
The observation of neutrinoless double-beta decay (0)
would show that lepton number is violated, reveal that neutrinos are Majorana
particles, and provide information on neutrino mass. A discovery-capable
experiment covering the inverted ordering region, with effective Majorana
neutrino masses of 15 - 50 meV, will require a tonne-scale experiment with
excellent energy resolution and extremely low backgrounds, at the level of
0.1 count /(FWHMtyr) in the region of the signal. The
current generation Ge experiments GERDA and the MAJORANA DEMONSTRATOR
utilizing high purity Germanium detectors with an intrinsic energy resolution
of 0.12%, have achieved the lowest backgrounds by over an order of magnitude in
the 0 signal region of all 0
experiments. Building on this success, the LEGEND collaboration has been formed
to pursue a tonne-scale Ge experiment. The collaboration aims to develop
a phased 0 experimental program with discovery potential
at a half-life approaching or at years, using existing resources as
appropriate to expedite physics results.Comment: Proceedings of the MEDEX'17 meeting (Prague, May 29 - June 2, 2017
The first search for bosonic super-WIMPs with masses up to 1 MeV/c with GERDA
We present the first search for bosonic super-WIMPs as keV-scale dark matter
candidates performed with the GERDA experiment. GERDA is a neutrinoless
double-beta decay experiment which operates high-purity germanium detectors
enriched in Ge in an ultra-low background environment at the Laboratori
Nazionali del Gran Sasso (LNGS) of INFN in Italy. Searches were performed for
pseudoscalar and vector particles in the mass region from 60 keV/c to 1
MeV/c. No evidence for a dark matter signal was observed, and the most
stringent constraints on the couplings of super-WIMPs with masses above 120
keV/c have been set. As an example, at a mass of 150 keV/c the most
stringent direct limits on the dimensionless couplings of axion-like particles
and dark photons to electrons of and
at 90% credible interval,
respectively, were obtained.Comment: 6 pages, 3 figures, submitted to Physical Review Letters, added list
of authors, updated ref. [21
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